Arthritis comprises a category of rheumatic diseases and associated conditions that are marked by joint inflammation. The symptoms connected with arthritis comprise joint pain, swelling, and stiffness. The most common types are osteoarthritis and rheumatoid arthritis, though there are many different forms. The treatment varies based on the cause; however, the goal is to ease pain and inflammation while retaining function. CBD, or Cannabidiol, plays a part in immune system modulation, which enables it to treat autoimmune conditions such as rheumatoid arthritis.
Moreover, the potent anti-inflammatory and analgesic properties of CBD and the interaction and suppression of specific receptors constitute CBD a potential sort of therapy for these conditions.
What Constitutes Arthritis?
Arthritis comprises mainly inflammation of joints, swelling, joint pain and stiffness. Different types of arthritis are present, with few common types comprising osteoarthritis, rheumatoid arthritis, polymyalgia rheumatica, psoriatic arthritis, ankylosing spondylitis, gout, pseudogout, Reiter’s disease, erythematosus, systemic lupus, fibromyalgia besides others. The most common forms of arthritis comprise Osteoarthritis and Rheumatoid arthritis. Rheumatoid arthritis is supposed to be chronic in nature, it occurs when the natural defense mechanism of the body goes haywire and begins attacking the body itself causing destruction of the joint. Osteoarthritis, however, results from wear and tear and is also termed degenerative osteoarthritis.
Causes Of Arthritis
The causes of arthritis are based on the form of arthritis. Causes comprise injury (resulting in osteoarthritis), the direct and indirect impact of infections (bacterial and viral), metabolic abnormalities (like gout with raised uric acid blood levels and pseudogout carrying hypercalcemia), hereditary factors, and a misdirected immune system with autoimmunity (like in systemic lupus erythematosus and rheumatoid arthritis).
Symptoms Of Arthritis
Arthritis impacts people in various ways and every condition carries specific symptoms. Nevertheless, common symptoms include:
- Muscular aches and pain
- Swelling, warmth, and redness in a joint
- Typical symptoms like fatigue and feeling unwell
- Stiffness or decreased movement of a joint
Occasionally, these symptoms are termed rheumatism. Rheumatism isn’t a disease in itself, though the term is occasionally employed to denote any type of joint or muscle pain.
How CBD Serves To Relieve Arthritis
CBD comprises an exogenous cannabinoid that influences the endocannabinoid system. CBD can transform the perception of pain and emotions that accompany physical distress. It also contains antioxidant and anti-inflammatory properties, which accounts for its capacity to aid people to handle their symptoms of arthritis.
CBD Suppresses T-Cells
T-cells constitute a group of white blood cells that cater to the immune system. T-cells along with the B lymphocytes signify the acquired immune response. These T-cells thereby represent a vital component of the human immune system.
Rheumatoid arthritis is amongst the autoimmune diseases whereby the immune response of the body can be focussed against the body’s individual processes/components, an overreaction of the immune system to the body’s individual non-pathogenic substances. The growth of T-cells aids to identify and fight foreign substances, which could present a danger to the body.
The creation of T-cells is also viewed as a co-causative agent in the progress of Rheumatoid arthritis. Research has indicated that the application of CBD suppresses the growth of these T-cells, which subsequently denotes one of the immunosuppressive properties of CBD, apart from its anti-inflammatory properties.
The quality of suppressing the growth of T-cells in the autoimmune disorder rheumatoid arthritis is among the advantages of the use of CBD in treating RA.
Effects On The Immune System In Arthritis
CBD also impacts the body’s immune system. Research has indicated that CBD can control and balance the overstimulation of the immune system. Overstimulation or overreaction frequently causes autoimmune disorders like multiple sclerosis, arthritis, psoriasis or generally chronic inflammation.
Patients of rheumatoid arthritis generally also have to fight joint inflammation. These inflammations are vested with severe pain and immobility. The potent anti-inflammatory properties of CBD might, thus, aid in chronic inflammatory processes in RA.
Acts As An Anti-Inflammatory
When the immune system erroneously attacks the joints, it results in inflammation due to the release of cytokines. Among the most prevalent cytokines comprises tumor necrosis factor (TNF). In arthritis, TNF is present within the joints and a primary cause of inflammation.
CBD lessens inflammation by suppressing the response of the immune system. A study indicates that by stimulating the TRPV1 receptors, CBD can lower inflammation in the joints resulting from TNF. The same study also displayed that CBD decreased pro-inflammatory biomarkers.
Reducing inflammation can prevent joint swelling, enhance the range of motion, lower stiffness, protect nerves from damage, and offer pain relief. The anti-inflammatory effect of CBD could be especially helpful for sufferers of rheumatoid arthritis.
Acts As An Analgesic
Besides reducing inflammation by interacting with TRPV1 receptors, CBD desensitizes the receptors, causing pain relief.
CBD also enhances the levels of an endocannabinoid that is a natural pain alleviator termed anandamide that interacts with TRPV1. By the inhibition of anandamide’s leading enzyme, CBD assists longer retention of anandamide in the body and offer analgesic effects.
CBD also aids to relieve pain by stopping glutamate neurotoxicity. Glutamate comprises a neurotransmitter and may be formed in excess during osteoarthritis according to research.
Excess production of glutamate can lead to neuron damage, creating pain for arthritis patients. However, CBD can restrict glutamate discharge and may offer pain relief, particularly for osteoarthritis sufferers.
Possesses Neuroprotective Effects
As noted by a study, CBD displayed Neuroprotective effects in the mice on administration prior to their inducement with osteoarthritis. This is crucial since neuron damage in the joints results in pain and comprises a factor in disease advancement.
Accordingly, protecting neurons may stop the pain and slow down disease or prevent it completely.
Oxidative stress and glutamate toxicity are believed to be two leading causes of neuronal damage and responsible for the development of arthritis.
As noted earlier, excess glutamate causes damage and ultimate destruction of nerve cells, however, CBD restricts glutamate production.
Oxidative stress occurs from a rise in reactive oxygen species (ROS), a chemical byproduct of the normal breakdown of oxygen in the human body. The rise leads to neuron damage and death, causing arthritic pain. rheumatoid arthritis, especially, has been displayed to induce oxidative stress.
However, studies have shown that CBD has been able to lower ROS-induced damage to neurons.
The potential of CBD as a Neuroprotective and preventative agent could assist numerous people who have a high propensity to arthritis and possibly stop its growth or assist those having initial stage arthritis slow down its advance.
Conclusion On CBD For Arthritis
CBD is relatively a potential safer therapy for arthritis compared to current medications that have adverse effects. CBD through its innate analgesic, antiproliferative, immunosuppressive, and anti-inflammatory properties have emerged as a viable treatment for joint inflammation and autoimmune ailments like rheumatoid arthritis.